If you have immediate relatives with age-related macular degeneration (AMD), the question of whether the disease is hereditary is a very personal one, often raising concerns about your own future vision health. In this article, we review what AMD is and discuss how family history and lifestyle factors play into a person’s overall risk for developing macular degeneration.
What is Macular Degeneration?
Age-related macular degeneration, more commonly known as just AMD, is an eye disease that affects the macula, which is the central part of the retina responsible for central vision. A simple way to think about the eye is like a camera. Light travels through the cornea, pupil, natural lens, and vitreous before reaching the retina at the back of the eye. The macula sits at the center of the retina, and its job is to help us see fine details clearly, whether that’s reading small print, recognizing faces, or telling colors apart. When the macula becomes damaged, these tasks become increasingly difficult.
For people with AMD, the experience is more than just “blurry vision.” While symptoms can vary widely, people with AMD cope with:
- Distorted or warped vision, such as straight lines appearing crooked, making text difficult to read
- Dark or blind spots in central vision
- Needing brighter lights, particularly when doing close-up work
- Changes in color vision, with colors appearing less vibrant or more difficult to distinguish
How Common is Macular Degeneration?
Age-related macular degeneration is a highly common condition. Affecting over 20 million Americans, it is the leading cause of vision loss for adults over the age of 50, though AMD’s prevalence is much higher in adults over 60.
Is Macular Degeneration Inherited?
For those who have relatives with AMD, this is the big question. The answer, unfortunately, is not a straightforward one. AMD is not usually inherited in a simple, direct way. Rather, it is a complex condition influenced by both genetics and lifestyle.
Studies indicate that having a first-degree relative—a parent or sibling, for example—with AMD means your risk is about 3 to 4 times higher compared to someone without that family history. Researchers have identified over 30 genes associated with the risk of developing AMD. This tells us there is a genetic component to AMD; however, association does not mean causation, and just because a person carries these genes does not guarantee they will develop AMD.
Genetics is not the only factor in whether someone will go on to develop the disease—lifestyle also plays a role. That means family history certainly matters, but it does not determine your future by itself. A useful way our low vision colleague in North Carolina, Dr. Edward L. Paul, Jr., OD, PhD, FIALVS, explains this is: “Genetics loads the gun, but lifestyle often pulls the trigger.”
What Lifestyle Factors Influence the Development of AMD?
There are a number of lifestyle factors that can influence the risk of developing age-related macular degeneration. These include:
- Smoking: Smoking is one of the strongest modifiable risk factors for AMD. Studies show smokers have a substantially higher risk of AMD than non-smokers, and smoking is repeatedly identified as an important environmental risk factor.
- Advanced age: While not a controllable risk factor unfortunately (if only!), advanced age is one of the leading factors in the development of AMD. The risk increases after the age of 60 and goes up with added years.
- Cardiovascular disease and high blood pressure: The eyes need healthy blood vessels to provide oxygen and nutrients. Conditions that decrease circulation, such as cardiovascular disease or high blood pressure, can reduce blood flow and increase the risk of macular degeneration.
- Poor nutrition: Nutrients such as lutein, zeaxanthin, omega-3 fatty acids, and vitamins C and E are critical to eye health, and a diet lacking in these is a known risk factor for AMD.
- Excess weight: Obesity and a sedentary lifestyle have been associated with a higher risk of developing macular degeneration.
- Long-term UV light exposure: Research has indicated that long-term exposure to UV light may contribute to retinal damage.
Can You Prevent Macular Degeneration?
Because AMD is a complex disease controlled by genetics and lifestyle factors, it is not possible to 100% prevent the disease. You can, however, significantly reduce your risk of it, or slow the progression of the disease if you’ve already been diagnosed, in several ways:
- Maintain a healthy lifestyle to reduce risk factors
- Consider an appropriate eye-health supplement, such as TOZAL
- Keep up with regular eye exams
- Consider photobiomodulation, or red light therapy, to slow or even reverse progression of the disease
Conclusion
While age-related macular degeneration does run in some families, it is only one piece of the puzzle. Developing AMD is not a certainty, and it does not always lead to significant vision loss or low vision. If AMD runs in your family, the most important thing you can do is live a healthy lifestyle and keep up with regular eye exams, as early detection allows for timely intervention, should changes be observed. If you are dealing with vision loss from macular degeneration, get in touch with us today. We’re here to help.
